Negative feedback buffers effects of regulatory variants
نویسندگان
چکیده
منابع مشابه
Negative feedback buffers effects of regulatory variants
Mechanisms conferring robustness against regulatory variants have been controversial. Previous studies suggested widespread buffering of RNA misexpression on protein levels during translation. We do not find evidence that translational buffering is common. Instead, we find extensive buffering at the level of RNA expression, exerted through negative feedback regulation acting in trans, which red...
متن کاملSupplementary information: Negative feedback buffers effects of regulatory variants
Standfirst text and highlights: Local trans regulation, mainly due to negative feedback, buffers effects of cis-regulatory variants by about 15%. This buffering is stronger for essential genes and genes with low to middle expression levels, for which tight regulation matters most. • Novel experimental design using expression of a diploid hybrid and its haploid spores allows systematic dissectio...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2015
ISSN: 1744-4292,1744-4292
DOI: 10.15252/msb.20145844